Best Examination Tips: Inherited Thrombophilia in O&G – themedideas Facts & Figures

  • Tuesday, January 8th, 2013

Updated on 30.10.2016.

Evidence based unbiased information

Inherited Thrombophilia is a group of inherited genetic defects leading to hypercoagulable state. It includes activated protein C (APC) resistance, hyperhomocysteinaemia, prothrombin gene G20210A mutation, protein C deficiency, antithrombin III deficiency, protein S deficiency, heparin cofactor II (HC II) deficiency, plasminogen or tissue plasminogen activator (TPA) deficiency, elevated plasminogen activator inhibitor-1 (PAI-1), dysfibrinogenemia,  abnormal thrombomodulin etc.

It is associated with up to 60% of women who developed thrombosis during pregnancy. The risk of thromboembolism increases with multiple defects. It is associated with several pregnancy complications such as recurrent miscarriage, second trimester miscarriage, intrauterine fetal death (IUFD), fetal growth restriction (FGR), pre-eclampsia, placental abruption and neonatal complications.

This is an overview of the conditions prepared after thorough review of the literature.

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